Synthesis of tetrafluorinated piperidines from nitrones via a visible-light-promoted annelation reaction

• Vyacheslav I. Supranovich,
• Igor A. Dmitriev and
• Alexander D. Dilman

Beilstein J. Org. Chem. 2020, 16, 3104–3108, doi:10.3762/bjoc.16.260

• implies multistep protocols, since two distinct bond-forming reactions are necessary for the cycle formation. While mono- and difluorinated piperidines are well known, tetrafluorinated piperidines are rare [19]. At the same time, the chemistry of compounds containing the tetrafluoroethylene fragment

Practical tetrafluoroethylene fragment installation through a coupling reaction of (1,1,2,2-tetrafluorobut-3-en-1-yl)zinc bromide with various electrophiles

• Ken Tamamoto,
• Shigeyuki Yamada and
• Tsutomu Konno

Beilstein J. Org. Chem. 2018, 14, 2375–2383, doi:10.3762/bjoc.14.213

• synthetic tool for producing functional molecules with a CF2CF2 fragment. Keywords: acid chlorides; cross-coupling; iodoarenes; tetrafluoroethylene fragment; thermally stable zinc reagent; Introduction Recently, much attention has been paid to organic compounds containing a perfluoroalkylene unit, e.g